Western Blot (WB)
(Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL. )
Rabbit anti-Mouse IL-31 Polyclonal Antibody | anti-Il31 antibody
IL-31 Antibody
Gene Names
Il31; 1700013B14Rik
Reactivity
Mouse
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
IL-31 Antibody is affinity chromatography purified via peptide column.
Synonyms
IL-31; Polyclonal Antibody; IL-31 Antibody; 1700013B14Rik; Interleukin-31; interleukin 31; anti-Il31 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
IL-31 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
163
Applicable Applications for anti-Il31 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-paraffin (IHC-P)
Application Notes
IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.
Conjugate
Unconjugated
Immunogen
IL-31 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of mouse IL-31.
The immunogen is located within amino acids 30 - 80 of IL-31.
The immunogen is located within amino acids 30 - 80 of IL-31.
Buffer
IL-31 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
IL-31 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL. )
Western Blot (WB)
(Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL. )
Immunohistochemistry (IHC)
(Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 μg/mL.)
Related Product Information for anti-Il31 antibody
IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
18,120 Da
NCBI Official Full Name
interleukin 31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
Il31
NCBI Official Synonym Symbols
1700013B14Rik
NCBI Protein Information
interleukin-31; IL-31
UniProt Protein Name
Interleukin-31
Protein Family
UniProt Gene Name
Il31
UniProt Synonym Gene Names
IL-31
UniProt Entry Name
IL31_MOUSE
Uniprot Description
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity
Protein type: Secreted; Secreted, signal peptide; Cytokine
Cellular Component: extracellular space; extracellular region
Molecular Function: cytokine activity
Biological Process: immune system process
Research Articles on Il31
Similar Products
Product Notes
The Il31 il31 (Catalog #AAA151553) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL-31 Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL-31 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry-paraffin (IHC-P). IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. Researchers should empirically determine the suitability of the Il31 il31 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-31, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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