Mouse anti-Human Muscleblind-like 1 Monoclonal Antibody | anti-MBNL1 antibody
Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428)
Reactivity
Human
Applications
Western Blot, Immunofluorescence
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
Muscleblind-like 1; Monoclonal Antibody; Muscleblind-like 1 (MBNL1; EXP35; EXP40; EXP42; Muscleblind-like; MBNL; MBNL Protein; Muscleblind 41kD Isoform; Triplet Expansion RNA Binding Protein; DKFZp686P06174; EXP; KIAA0428); Anti -Muscleblind-like 1 (MBNL1; anti-MBNL1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
8L845
Specificity
This antibody is specific for MBNL 1p protein. Species Crossreactivity: This antibody works in human samples
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
Applicable Applications for anti-MBNL1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes
Suitable for use in Immunofluorescence and Western Blot.
Immunogen
Fusion muscleblind-like1p/p60 human protein. Epitope: Amino acids 116-182.
Cellular Localization
Nuclear
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50%glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-MBNL1 antibody
Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.
Product Categories/Family for anti-MBNL1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39,670 Da
NCBI Official Full Name
muscleblind-like protein 1 isoform 5
NCBI Official Synonym Full Names
muscleblind-like (Drosophila)
NCBI Official Symbol
MBNL1
NCBI Protein Information
muscleblind-like protein 1; muscleblind-like 1
UniProt Protein Name
Muscleblind-like protein 1
Protein Family
UniProt Gene Name
MBNL1
UniProt Entry Name
MBNL1_CHICK
Uniprot Description
Function: Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA
By similarity.
Subcellular location: Nucleus
By similarity. Cytoplasm
By similarity. Cytoplasmic granule
By similarity.
Sequence similarities: Belongs to the muscleblind family.Contains 4 C3H1-type zinc fingers.
Research Articles on MBNL1
Similar Products
Product Notes
The MBNL1 mbnl1 (Catalog #AAA601399) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Muscleblind-like 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Researchers should empirically determine the suitability of the MBNL1 mbnl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Muscleblind-like 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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