Goat anti-Human Muscleblind-like 1 Polyclonal Antibody | anti-MBNL1 antibody

Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428)

Cat. Num. AAA623282

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Muscleblind-like 1; Polyclonal Antibody; Muscleblind-like 1 (MBNL1; EXP35; EXP40; EXP42; Muscleblind-like; MBNL; MBNL Protein; Muscleblind 41kD Isoform; Triplet Expansion RNA Binding Protein; DKFZp686P06174; EXP; KIAA0428); Anti -Muscleblind-like 1 (MBNL1; anti-MBNL1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human MBNL1. Species sequence homology: mouse, rat, canine, bovine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-MBNL1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Peptide ELISA: 1:,000.; Western Blot: 1-3ug/ml. Optimal dilutions to be determined by the researcher.
• Immunogen: A synthetic peptide from the C-terminus of aa-SAEHLTSHKYVTQ
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Related Product Information for anti-MBNL1 antibody

Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.

Product Categories/Family for anti-MBNL1 antibody

Antibodies; Abs to RNA Processing

NCBI and Uniprot Product Information

• NCBI GI #: 254039624
• NCBI GeneID: 425033
• NCBI Accession #: NP_001156799.1
• NCBI GenBank Nucleotide #: NM_001163327.2
• UniProt Accession #: Q5ZKW9
• Molecular Weight: 39,670 Da
• NCBI Official Full Name: muscleblind-like protein 1 isoform 5
• NCBI Official Synonym Full Names: muscleblind-like (Drosophila)
• NCBI Official Symbol: MBNL1
• NCBI Protein Information: muscleblind-like protein 1; muscleblind-like 1
• UniProt Protein Name: Muscleblind-like protein 1
• Protein Family: Muscleblind-like protein
• UniProt Gene Name: MBNL1
• UniProt Entry Name: MBNL1_CHICK

Uniprot Description

Function: Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA

By similarity.

Subcellular location: Nucleus

By similarity. Cytoplasm

By similarity. Cytoplasmic granule

By similarity.

Sequence similarities: Belongs to the muscleblind family.Contains 4 C3H1-type zinc fingers.