Mouse anti-Human LAIR-1 Monoclonal Antibody | anti-LAIR-1 antibody

LAIR-1 (Leukocyte-associated Ig-like Receptor-1) (HRP)

Cat. Num. AAA6251024

• Gene Names: LAIR1; CD305; LAIR-1
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
• Purity: Purified by protein A affinity chromatography from tissue culture supernatant.
• Synonyms: LAIR-1; Monoclonal Antibody; LAIR-1 (Leukocyte-associated Ig-like Receptor-1) (HRP); anti-LAIR-1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 4j59
• Specificity: Recognizes human leukocyte-associated Ig-like receptor-1 (LAIR-1), 40kD. Reported to inhibit NK cell triggering via CD16 molecules (1).
• Purity/Purification: Purified by protein A affinity chromatography from tissue culture supernatant.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Labeled with horseradish peroxidase (HRP).

• Applicable Applications for anti-LAIR-1 antibody: Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)
• Immunogen: NK cells lines B12.100 and AM.25
• Conjugate: HRP
• Preparation and Storage: Store at -20 degree C.

Product Categories/Family for anti-LAIR-1 antibody

Antibodies; Receptors

References

1. Poggi, A. et al. (1995). p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur. J. Immunol. 25: 369 - 376. 2. Zocchi, M. R. et al. (2001). Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur. J. Immunol. 31: 3667 - 3675. 3. Poggi, A. et al. (2000). Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents nuclear translocation in human myeloid leukemias. Eur. J. Immunol. 30: 2751 - 2758.

NCBI and Uniprot Product Information

• NCBI GI #: 612407867
• NCBI GeneID: 3903
• NCBI Accession #: NP_001275952.2
• NCBI GenBank Nucleotide #: NM_001289023.2
• UniProt Accession #: Q6GTX8
• Molecular Weight: 23,049 Da
• NCBI Official Full Name: leukocyte-associated immunoglobulin-like receptor 1 isoform c
• NCBI Official Synonym Full Names: leukocyte-associated immunoglobulin-like receptor 1
• NCBI Official Symbol: LAIR1
• NCBI Official Synonym Symbols: CD305; LAIR-1
• NCBI Protein Information: leukocyte-associated immunoglobulin-like receptor 1; leukocyte-associated Ig-like receptor 1
• UniProt Protein Name: Leukocyte-associated immunoglobulin-like receptor 1
• UniProt Gene Name: LAIR1
• UniProt Synonym Gene Names: CD305; LAIR-1; hLAIR1
• UniProt Entry Name: LAIR1_HUMAN

NCBI Description

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: immune system process