Rabbit TEAD1 Polyclonal Antibody | anti-TEAD1 antibody

TEAD1 Rabbit Polyclonal

Cat. Num. AAA7604814

• Gene Names: TEAD1; AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TEAD1; Polyclonal Antibody; TEAD1 Rabbit Polyclonal; anti-TEAD1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 357

• Applicable Applications for anti-TEAD1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: TEA domain family member 1 (SV40 transcriptional enhancer factor)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemical of paraffin-embedded human liver cancer using MBS7604814 (TEAD1 antibody) at dilution of 1:50)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7604814 (TEAD1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 133777909
• NCBI GeneID: 7003
• Molecular Weight: 40,000 Da
• NCBI Official Full Name: TEAD1 protein
• NCBI Official Synonym Full Names: TEA domain transcription factor 1
• NCBI Official Symbol: TEAD1
• NCBI Official Synonym Symbols: AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1
• NCBI Protein Information: transcriptional enhancer factor TEF-1
• UniProt Protein Name: Transcriptional enhancer factor TEF-1
• Protein Family: Transcriptional enhancer factor
• UniProt Gene Name: TEAD1
• UniProt Synonym Gene Names: TCF13; TEF1; TEAD-1; TCF-13
• UniProt Entry Name: TEAD1_HUMAN

NCBI Description

This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

Uniprot Description

TEAD1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: nucleoplasm

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter

Disease: Sveinsson Chorioretinal Atrophy