Western Blot (WB)
(Kappa light chain Antibody western blot analysis in human serum protein (35ug/lane).This demonstrates the Kappa light chain antibody detected the Kappa light chain protein (arrow).)
Mouse anti-Human Kappa light chain Monoclonal Antibody | anti-IGKC antibody
Kappa light chain Antibody
Gene Names
IGKC; Km; HCAK1; IGKCD
Reactivity
Human
Applications
ELISA, Immunohistochemistry, Western Blot
Synonyms
Kappa light chain; Monoclonal Antibody; Kappa light chain Antibody; Ig kappa chain C region; IGKC; anti-IGKC antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
HP6053
Specificity
This Kappa light chain monoclonal antibody is generated from mouse immunized with Kappa light chain recombinant protein.
Form/Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Length
106
Applicable Applications for anti-IGKC antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes
WB~~1:100~1000
IHC~~1:10~50
IHC~~1:10~50
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(Kappa light chain Antibody western blot analysis in human serum protein (35ug/lane).This demonstrates the Kappa light chain antibody detected the Kappa light chain protein (arrow).)
Western Blot (WB)
(Kappa light chain Antibody western blot analysis in human serum protein (35ug/lane).This demonstrates the Kappa light chain antibody detected the Kappa light chain protein (arrow).)
Immunohistochemistry (IHC)
(Kappa light chain Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kappa light chain Antibody for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Kappa light chain Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kappa light chain Antibody for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-IGKC antibody
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two types of light chains designated as kappa and lambda (1). Light chain types are based on differences in the amino acid sequence in the constant region of the light chain. If a cell is unsuccessful in rearranging both of its kappa light chain genes, it then attempts to make a lambda light chain. If a cell successfully rearranges a lambda light chain gene, it will be a B cell that makes an immunoglobulin with a lambda light chain (2).
Product Categories/Family for anti-IGKC antibody
References
58066: Reimer CB, et al. Evaluation of thirty-one mouse monoclonal antibodies to human IgG epitopes. Hybridoma 3: 263-275, 1984. PubMed: 6209201
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
11609
NCBI Official Full Name
Ig kappa chain C region
NCBI Official Synonym Full Names
immunoglobulin kappa constant
NCBI Official Symbol
IGKC
NCBI Official Synonym Symbols
Km; HCAK1; IGKCD
UniProt Protein Name
Ig kappa chain C region
UniProt Gene Name
IGKC
UniProt Entry Name
IGKC_HUMAN
Uniprot Description
IGKC: Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD). IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: extracellular space; extracellular region; plasma membrane
Molecular Function: antigen binding
Biological Process: retinal homeostasis; receptor-mediated endocytosis; regulation of immune response; innate immune response; immune response; complement activation, classical pathway; complement activation
Research Articles on IGKC
Similar Products
Product Notes
The IGKC igkc (Catalog #AAA9200456) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Kappa light chain Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Kappa light chain can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). WB~~1:100~1000 IHC~~1:10~50. Researchers should empirically determine the suitability of the IGKC igkc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kappa light chain, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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