Mouse anti-Human G-CSF Receptor Monoclonal Antibody | anti-CSF3R antibody

Anti-G-CSF Receptor (G-CSFR, GCSFR, CSF3R, Granulocyte Colony-stimulating Factor Receptor, G-CSF-R, CD114)

Cat. Num. AAA631933

• Gene Names: CSF3R; CD114; GCSFR
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Western Blot
• Purity: Affinity Purified
• Synonyms: G-CSF Receptor; Monoclonal Antibody; Anti-G-CSF Receptor (G-CSFR; GCSFR; CSF3R; Granulocyte Colony-stimulating Factor Receptor; G-CSF-R; CD114); G-CSFR; CD114; anti-CSF3R antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 11C109
• Specificity: Recognizes human GCSFR.
• Purity/Purification: Affinity Purified
• Form/Format: Supplied as a liquid in PBS, 1% trehalose.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-CSF3R antibody: ELISA; Western Blot; Flow Cytometry
• Application Notes: Suitable for use in Western Blot, ELISA and Flow Cytometry.; Recommended Dilutions: Western Blot: 1-3ug/ml (chemiluminescence); ELISA: 1:10,000-1:100,000 (using 50-100ng of control protein/well).; Flow Cytometry: ~20-30ug/ml in human PBMC cells.
• Immunogen: Recombinant corresponding to human GCSFR, expressed in E.coli.
• Source Information: Human
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.; Shipping Temperature: Blue Ice

Related Product Information for anti-CSF3R antibody

GCSF (G-CSF, CSF3), is a glycoprotein that is produced and secreted by macrophages stimulated with endotoxin. Cell activation by G-CSF is mediated by a type I membrane protein belonging to the cytokine receptor superfamily. Human G-CSF R is 863aa (23aa signal peptide, 604aa extracellular domain, a 26aa transmembrane domain, and a 183aa cytoplasmic domain). As a result of alternative splicing, at least four isoforms of G-CSF R that differ in their C- terminal region exist. Isoform 2 lacks the transmembrane region and may represent a soluble form of the receptor; however the existence of soluble G-CSF R in human serum has not been reported. Human and mouse G-CSF R have a homology of 62.5%. G-CSF R is expressed in mature neutrophils, neutrophilic precursors, myeloid leukemia cells, and placenta. Binding of G-CSF to its receptor induces dimerization or oligomerization of the receptor activating cytoplasmic tyrosine kinases. Signal transduction from pathways that involve Janus tyrosine kinases/signal transducer and activator of transcription proteins (Jak1, Jak2, and Tyk2/STAT3, STAT3, and STATG), src-related protein tyrosine kinases (Lyn and Syk), Ras/MAP kinase, and phosphatidylinositol have been reported to be activated upon G-CSF stimulation.

Product Categories/Family for anti-CSF3R antibody

Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 485364
• NCBI GeneID: 1441
• UniProt Accession #: Q1ZYL6; Q59F05; Q99062
• Molecular Weight: 92,122 Da
• NCBI Official Full Name: granulocyte colony-stimulating factor receptor
• NCBI Official Synonym Full Names: colony stimulating factor 3 receptor (granulocyte)
• NCBI Official Symbol: CSF3R
• NCBI Official Synonym Symbols: CD114; GCSFR
• NCBI Protein Information: granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor; OTTHUMP00000009703; OTTHUMP00000009704; OTTHUMP00000009705
• UniProt Protein Name: Granulocyte colony-stimulating factor receptor
• Protein Family: Granulocyte colony-stimulating factor receptor
• UniProt Entry Name: Q1ZYL6_HUMAN