Rabbit anti-Human GCSF Receptor Polyclonal Antibody | anti-CSF3R antibody

Polyclonal Anti-CSF3R Antibody

Cat. Num. AAA176365

• Gene Names: CSF3R; CD114; GCSFR
• Reactivity: Human
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: GCSF Receptor; Polyclonal Antibody; Polyclonal Anti-CSF3R Antibody; Granulocyte colony-stimulating factor receptor; Colony stimulating factor 3 receptor(granulocyte); CD 114 antibody; CD114 antibody; CD114 antigen antibody; Colony stimulating factor 3 receptor(granulocyte) antibody; Colony stimulating factor 3 receptor antibody; CSF 3R antibody; CSF3R antibody; CSF3R_HUMAN antibody; Csfgr antibody; G CSF R antibody; G-CSF receptor antibody; G-CSF-R antibody; GCSFR antibody; Granulocyte colony stimulating factor receptor antibody; Granulocyte colony stimulating factor receptor precursor antibody; Granulocyte colony-stimulating factor receptor antibody; OTTHUMP00000009703 antibody; OTTHUMP00000009704 antibody; OTTHUMP00000009705 antibody; anti-CSF3R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 836

• Applicable Applications for anti-CSF3R antibody: Western Blot (WB)
• Application Notes: Western Blot:; Concentration: 0.1-0.5ug/ml; Tested Species: Hu; WB: The detection limit for CSF3R is approximately 5ng/lane under reducing conditions.; ; Tested Species: In-house tested species with positive results.; Predicted Species: species predicted to be fit for the product based on sequence similarities.; Other applications have not been tesetd.; Optimal dilutions should be determined by end users.
• Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human GCSF Receptor (254-271aa EPWQPGLHINQKCELRHK).
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-GCSF Receptor antibody, MBS176365, Western blottingWB: Human Placenta Tissue Lysate )

Related Product Information for anti-CSF3R antibody

Description: Rabbit IgG polyclonal antibody for Granulocyte colony-stimulating factor receptor(CSF3R) detection. Tested with WB in Human.
Background: CSF3R(Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114((Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor(G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The CSF3R gene consists of 17 exons. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

NCBI and Uniprot Product Information

• NCBI GI #: 729564
• NCBI GeneID: 1441
• UniProt Accession #: Q99062
• NCBI Official Full Name: Granulocyte colony-stimulating factor receptor
• NCBI Official Synonym Full Names: colony stimulating factor 3 receptor (granulocyte)
• NCBI Official Symbol: CSF3R
• NCBI Official Synonym Symbols: CD114; GCSFR
• NCBI Protein Information: granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor
• UniProt Protein Name: Granulocyte colony-stimulating factor receptor
• Protein Family: Granulocyte colony-stimulating factor receptor
• UniProt Gene Name: CSF3R
• UniProt Synonym Gene Names: GCSFR; G-CSF receptor; G-CSF-R
• UniProt Entry Name: CSF3R_HUMAN

NCBI Description

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]

Uniprot Description

GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35-p34.3

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity

Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; cell adhesion; signal transduction

Disease: Neutrophilia, Hereditary