Western Blot (WB)
(Western Blot using anti-folate receptor antibody Mouse heart (lane 1), mouse lung (lane 2), mouse pancreas (lane 3), mouse testis (lane 4) and rat ovary (lane 5)samples were resolved on a 12% SDS PAGE gel and blots probed at 1.5 ug/ml before being detected by a secondary antibody. Bands correspondig to the expected 29 kDa folate receptor protein as well as dimers thereof were detected.)
Folate Receptor beta Recombinant Antibody | Frbeta recombinant antibody
Anti-Folate Receptor beta [CL10]
Western Blot (WB)
(Western Blot using anti-folate receptor antibody Mouse heart (lane 1), mouse lung (lane 2), mouse pancreas (lane 3), mouse testis (lane 4) and rat ovary (lane 5)samples were resolved on a 12% SDS PAGE gel and blots probed at 1.5 ug/ml before being detected by a secondary antibody. Bands correspondig to the expected 29 kDa folate receptor protein as well as dimers thereof were detected.)
Western Blot (WB)
(Western Blot using anti-folate receptor antibody Mouse heart (lane 1), mouse lung (lane 2), mouse pancreas (lane 3), mouse testis (lane 4) and rat ovary (lane 5)samples were resolved on a 12% SDS PAGE gel and blots probed at 1.5 ug/ml before being detected by a secondary antibody. Bands correspondig to the expected 29 kDa folate receptor protein as well as dimers thereof were detected.)
Original Published Journal: Cancer Immunol Immunother. 2009 Oct;58(10):1577-86.
Original Published Journal: Cancer Immunol Immunother. 2009 Oct;58(10):1577-86.
Publication Note: Describes the expression of folate receptor beta on macrophages in glioblastomas, and the production of an antibody against the receptor which can reduce tumour growth.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Description
FOLR2: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Belongs to the folate receptor family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 7|7 E2
Cellular Component: anchored to external side of plasma membrane; cell surface
Molecular Function: drug binding; folic acid binding; folic acid transporter activity; methotrexate binding
Biological Process: folic acid transport; positive regulation of cell proliferation; posttranslational protein targeting to membrane
Research Articles on Frbeta
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Product Notes
The Frbeta folr2 (Catalog #AAA488432) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Folate Receptor beta [CL10] reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Folate Receptor beta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the Frbeta folr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Folate Receptor beta, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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