Mouse anti-Human Fibromodulin Monoclonal Antibody | anti-FMOD antibody
Fibromodulin (FMOD, FM, Collagen-binding 59kD Protein)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: ELISA: 0.5-1ug/ml
Western Blot: 2ug/ml
Western Blot (WB)
(Western Blot shows lysates of human cartilage tissue. PVDF membrane was probed with MBS608379 (2ug/ml) folllowed by IgG (HRP) anti-mouse secondary antibody. A specific band was detected for Fibromodulin at ~55kD (as indicated). This experiment was conducted under reducing conditions.)
NCBI and Uniprot Product Information
NCBI Description
Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. [provided by RefSeq]
Uniprot Description
FMOD: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; extracellular space; Golgi lumen; extracellular region
Biological Process: transforming growth factor beta receptor complex assembly; keratan sulfate metabolic process; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; carbohydrate metabolic process; keratan sulfate biosynthetic process; pathogenesis; keratan sulfate catabolic process
Research Articles on FMOD
2. tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors
3. differentially expressed in mesenchymal stromal cell subset with reduced differentiation potential
4. Observational study of gene-disease association. (HuGE Navigator)
5. Ultraviolet B and A irradiation induce FMOD expression in fibroblasts in vitro.
6. Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding.
7. CD200 blockade was further shown to stimulate antigen-specific T cell responses towards the CLL-associated antigen fibromodulin
8. Specific decorin and fibromodulin core protein fragments in degenerate meniscus and/or human articular cartilage may be of value as biomarkers of disease.
9. Fibromodulin gene is constantly expressed in human epidermal keratinocytes.
10. The collagen-binding Glu-353 and Lys-355 residues in fibromodulin are exposed on the exterior of the beta-sheet-loop structure of the leucine-rich repeat, which resembles the location of interacting residues in other leucine-rich repeat proteins.
Similar Products
Product Notes
The FMOD fmod (Catalog #AAA608379) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Fibromodulin (FMOD, FM, Collagen-binding 59kD Protein) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Fibromodulin can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 0.5-1ug/ml Western Blot: 2ug/ml. Researchers should empirically determine the suitability of the FMOD fmod for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fibromodulin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.