Fibromodulin Recombinant Protein | FMOD recombinant protein

Fibromodulin Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8120836

• Gene Names: FMOD; FM; SLRR2E
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Fibromodulin; Fibromodulin Protein; Human; Recombinant (hFc Tag); Human FMOD/fibromodulin Protein (Fc Tag); FM Protein; SLRR2E Protein; fibromodulin; FMOD recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ile376

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gln 19
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human FMOD (NP_002014.2)(Met1-Ile376) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for FMOD recombinant protein

Background: Fibromodulin (FMOD), an ECM small leucine-rich proteoglycan (SLRP), was reported to promote angiogenesis not only during wound healing, but also in optical and cutaneous angiogenesis-dependent diseases. The autocrine FMOD of cancer cells may promote tumor angiogenesis of SCLC by upregulating the expression of angiogenic factors that act in concert to facilitate the angiogenic phenotype of endothelial cells as a proangiogenic factor. Therefore, silencing FMOD may be a potentially clinical therapy for repressing tumor angiogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 71040111
• NCBI GeneID: 2331
• NCBI Accession #: NP_002014.2
• NCBI GenBank Nucleotide #: NM_002023.4
• UniProt Accession #: Q06828; Q15331; Q8IV47
• Molecular Weight: 43,179 Da
• NCBI Official Full Name: fibromodulin
• NCBI Official Synonym Full Names: fibromodulin
• NCBI Official Symbol: FMOD
• NCBI Official Synonym Symbols: FM; SLRR2E
• NCBI Protein Information: fibromodulin; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate proteoglycan fibromodulin
• UniProt Protein Name: Fibromodulin
• Protein Family: Fibromodulin
• UniProt Gene Name: FMOD
• UniProt Synonym Gene Names: FM; SLRR2E; FM
• UniProt Entry Name: FMOD_HUMAN

NCBI Description

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

FMOD: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; lysosomal lumen; Golgi lumen; extracellular region

Biological Process: keratan sulfate metabolic process; transforming growth factor beta receptor complex assembly; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; carbohydrate metabolic process; keratan sulfate biosynthetic process; pathogenesis; keratan sulfate catabolic process