Rabbit anti-Human DR6/TNFRSF21  Monoclonal Antibody | anti-DR6/TNFRSF21  antibody

Rabbit anti Human DR6/TNFRSF21  Monoclonal Antibody

Cat. Num. AAA2543871

• Gene Names: Tnfrsf21; DR6; TR7; R74815; AA959878
• Reactivity: Human
• Applications: ELISA
• Synonyms: DR6/TNFRSF21 ; Monoclonal Antibody; Rabbit anti Human DR6/TNFRSF21 Monoclonal Antibody; anti-DR6/TNFRSF21 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 655

• Applicable Applications for anti-DR6/TNFRSF21 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human DR6. The detection limit for Human DR6 is approximately 0.039 ng/well.
• Immunogen: Recombinant Human DR6 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF21 (rh TNFRSF21; Met 1-Leu 350; NP_055267.1).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-DR6/TNFRSF21  antibody

TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

NCBI and Uniprot Product Information

• NCBI GI #: 11559850
• NCBI GeneID: 94185
• Molecular Weight: 71,983 Da
• NCBI Official Full Name: DR6
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 21
• NCBI Official Symbol: Tnfrsf21
• NCBI Official Synonym Symbols: DR6; TR7; R74815; AA959878
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 21
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 21
• UniProt Gene Name: Tnfrsf21
• UniProt Synonym Gene Names: Dr6
• UniProt Entry Name: TNR21_MOUSE

Uniprot Description

DR6: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Associates with TRADD. Interacts with N-APP. Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Protein type: Apoptosis; Membrane protein, integral; Receptor, cytokine

Cellular Component: axon; integral to plasma membrane; intrinsic to plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: adaptive immune response; apoptosis; B cell apoptosis; humoral immune response; inflammatory response; myelination; negative regulation of B cell proliferation; negative regulation of myelination; negative regulation of T cell proliferation; neuron apoptosis; regulation of apoptosis; regulation of oligodendrocyte differentiation; response to lipopolysaccharide; T cell receptor signaling pathway