Rabbit anti-Human CD89/FCAR Monoclonal Antibody | anti-CD89/FCAR antibody
Rabbit anti Human CD89/FCAR Monoclonal Antibody
Gene Names
Fcar; CD89
Reactivity
Human
Applications
ELISA
Synonyms
CD89/FCAR ; Monoclonal Antibody; Rabbit anti Human CD89/FCAR Monoclonal Antibody; anti-CD89/FCAR antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Sequence Length
105
Applicable Applications for anti-CD89/FCAR antibody
ELISA (EIA)
Application Notes
ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CD89. The detection limit for Human CD89 is 0.0049 ng/well.
Immunogen
Recombinant Human CD89 protein
Buffer
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD89/FCAR (rh CD89; NP_001991.1; Met 1-Asn 227).
Preparation and Storage
This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-CD89/FCAR antibody
FCAR, also called FcalphaRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcalphaRI associates with the FcR gamma signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcalphaRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcalphaRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
NCBI and Uniprot Product Information
Research Articles on CD89/FCAR
Similar Products
Product Notes
The CD89/FCAR (Catalog #AAA2543982) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human CD89/FCAR Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD89/FCAR can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CD89. The detection limit for Human CD89 is 0.0049 ng/well. Researchers should empirically determine the suitability of the CD89/FCAR for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD89/FCAR , Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
