CD89 Recombinant Protein | FCAR recombinant protein

CD89 Protein, Human, Recombinant (ECD, His Tag)

Cat. Num. AAA8120255

• Gene Names: FCAR; CD89; FCAR
• Purity: >97% as determined by SDS-PAGE
• Synonyms: CD89; CD89 Protein; Human; Recombinant (ECD; His Tag); Human CD89/FCAR Protein (ECD; CTB-61M7.2 Protein; FcalphaRI Protein; FCAR Protein; XXbac-BPG230H20.5 Protein; Fc fragment of IgA receptor; FCAR recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >97% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asn227

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 22
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human FCAR (NP_001991.1)(Met1-Asn227) was expressed with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FCAR recombinant protein

Background: FCAR, also called FcalphaRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcalphaRI associates with the FcR gamma signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcalphaRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcalphaRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

Product Categories/Family for FCAR recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules Fc Receptors

References

Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.

NCBI and Uniprot Product Information

• NCBI GI #: 4503673
• NCBI GeneID: 2204
• UniProt Accession #: P24071; Q13603; Q13604; Q15727; Q15728; Q1AJL7; Q1AJL8; Q1AJL9; Q53X38; Q92590
• NCBI Official Full Name: immunoglobulin alpha Fc receptor isoform a [Homo sapiens]
• NCBI Official Synonym Full Names: Fc fragment of IgA, receptor for
• NCBI Official Symbol: FCAR
• NCBI Official Synonym Symbols: CD89; FCAR
• UniProt Protein Name: Immunoglobulin alpha Fc receptor
• Protein Family: Immunoglobulin alpha Fc receptor
• UniProt Gene Name: FCAR
• UniProt Synonym Gene Names: CD89; IgA Fc receptor

Uniprot Description

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.