Cluster Of Differentiation 247 (CD247) Recombinant Protein | CD247 recombinant protein

Recombinant Cluster Of Differentiation 247 (CD247)

Cat. Num. AAA2097670

• Gene Names: CD247; T3Z; CD3H; CD3Q; CD3Z; TCRZ; IMD25; CD3-ZETA
• Reactivity: Human
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Cluster Of Differentiation 247 (CD247); Recombinant Cluster Of Differentiation 247 (CD247); CD3-ZETA; CD3H; CD3Q; CD3Z; TCRZ; TCR-Z; T-Cell Receptor Zeta; CD3z Antigen; Zeta Polypeptide TiT3 Complex; T-cell receptor T3 zeta chain; CD247 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 63

• Applicable Applications for CD247 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: N-terminal His Tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Fragment: Met1~Leu160

SDS-Page

Product Categories/Family for CD247 recombinant protein

Signal transduction; CD & Adhesion molecule; Tumor immunity; Infection immunity

NCBI and Uniprot Product Information

• NCBI GI #: 157956447
• NCBI GeneID: 919
• Molecular Weight: Predicted Molecular Weight: 19.9kDa
• NCBI Official Full Name: CD247, partial
• NCBI Official Synonym Full Names: CD247 molecule
• NCBI Official Symbol: CD247
• NCBI Official Synonym Symbols: T3Z; CD3H; CD3Q; CD3Z; TCRZ; IMD25; CD3-ZETA
• NCBI Protein Information: T-cell surface glycoprotein CD3 zeta chain
• UniProt Protein Name: T-cell surface glycoprotein CD3 zeta chain
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD247
• UniProt Synonym Gene Names: CD3Z; T3Z; TCRZ

NCBI Description

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: alpha-beta T cell receptor complex; cytoplasm; integral component of membrane; plasma membrane; T cell receptor complex

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity

Biological Process: adaptive immune response; Fc-gamma receptor signaling pathway involved in phagocytosis; protein homotetramerization; regulation of defense response to virus by virus; regulation of immune response; T cell costimulation; T cell receptor signaling pathway

Disease: Immunodeficiency 25