Dilution Information
Mouse anti-Human CD147 Monoclonal Antibody | anti-CD147 antibody
CD147 (BSB-137)
Reactivity
Human
Synonyms
CD147; Monoclonal Antibody; CD147 (BSB-137); cd147; cd-147 cd 147; anti-cd147; anti-cd-147; cd147 antibody; anti-cd147 antibody; sars-cov-2 receptors; sars cov-2 receptors; covid-19 receptors; sars-cov-2 antibodies sars-cov-2 ihc; sars-cov-2 immunohistochemistry; anti-CD147 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-137
Form/Format
Paraffin, Frozen
CD147 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CD147 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant protein corresponding to the extracellular domain of the human CD147 protein.
Control
Testis, Colon, Kidney, Stomach, Brain
Localization
Membranous, Cytoplasmic
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(CD147 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue)
Immunohistochemistry (IHC)
(CD147 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue)
Related Product Information for anti-CD147 antibody
CD147 is a transmembrane glycoprotein also known as Basigin or EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), participating in tumor development and viral entry pathways. CD147 is a member of the immunoglobulin superfamily, upregulated in asthmatic, diabetic, and other inflammatory pathways where it induces expression of Matrix Metalloproteinase 1 and 9. CD147 and its effectors are induced by high-glucose concentration in monocytes and promote their migration. CD147 also participates in fibroblast differentiation through TGF-b1-induced signaling pathways, and is a marker of undifferentiated human embryonic stem cells.
CD147 antibody has been found to be upregulated in cancer stem cells, resulting in increased metabolism through lactic acid export, increased production of hyaluronan, inhibiting apoptosis, and acting as a main upstream stimulator of matrix metalloproteinases. In clinical studies, CD147 has been associated with larger tumors, deeper invasion, and more lymphocytes. CD147 also facilitates the entry of malaria parasite Plasmodium falciparum into red blood cells, and the entry of coronaviruses into human cells by binding the spike glycoprotein, functioning as the second receptor for SARS-CoV-2 and potential participant in pulmonary fibrosis.
CD147 antibody has been found to be upregulated in cancer stem cells, resulting in increased metabolism through lactic acid export, increased production of hyaluronan, inhibiting apoptosis, and acting as a main upstream stimulator of matrix metalloproteinases. In clinical studies, CD147 has been associated with larger tumors, deeper invasion, and more lymphocytes. CD147 also facilitates the entry of malaria parasite Plasmodium falciparum into red blood cells, and the entry of coronaviruses into human cells by binding the spike glycoprotein, functioning as the second receptor for SARS-CoV-2 and potential participant in pulmonary fibrosis.
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Product Notes
The CD147 (Catalog #AAA370470) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD147 (BSB-137) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD147, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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