ILT6 / LILRA3 recombinant protein

Recombinant Human ILT6 / LILRA3 Protein (His tag)

Cat. Num. AAA2545284

• Gene Names: LILRA3; HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
• Purity: > 85 % as determined by SDS-PAGE
• Synonyms: ILT6 / LILRA3; Recombinant Human ILT6 / LILRA3 Protein (His tag); LILRA3; ILT6; LIR4; ILT6 / LILRA3 recombinant protein

• Host: Human Cells
• Purity/Purification: > 85 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 439

• Application Notes: The recombinant human LILRA3 consists of 427 amino acids and predicts a molecular mass of 46.5 KDa. It migrates as an approximately 57-66 KDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Gly 24
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for ILT6 / LILRA3 recombinant protein

Background: ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

Description: A DNA sequence encoding the human LILRA3 (AAH28208.1) (Met1-Glu439) was expressed with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 20381359
• NCBI GeneID: 11026
• Molecular Weight: 49,187 Da
• NCBI Official Full Name: Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A3
• NCBI Official Symbol: LILRA3
• NCBI Official Synonym Symbols: HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 3
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 3
• UniProt Gene Name: LILRA3
• UniProt Synonym Gene Names: ILT6; LIR4; ILT-6; LIR-4

NCBI Description

This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

Uniprot Description

LILRA3: May act as soluble receptor for class I MHC antigens.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane

Molecular Function: antigen binding; receptor activity

Biological Process: defense response; signal transduction