Rabbit anti-Human, Mouse TMEM106B Polyclonal Antibody | anti-TMEM106B antibody

TMEM106B Rabbit Polyclonal

Cat. Num. AAA7604977

• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TMEM106B; Polyclonal Antibody; TMEM106B Rabbit Polyclonal; anti-TMEM106B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 274

• Applicable Applications for anti-TMEM106B antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
• Immunogen: Transmembrane protein 106B
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain using MBS7604977 (TMEM106B antibody) at dilution of 1:100)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7604977 (TMEM106B antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 197116389
• NCBI GeneID: 54664
• NCBI Accession #: NP_001127704.1
• NCBI GenBank Nucleotide #: NM_001134232.1
• Molecular Weight: 31,127 Da
• NCBI Official Full Name: transmembrane protein 106B
• NCBI Official Synonym Full Names: transmembrane protein 106B
• NCBI Official Symbol: TMEM106B
• NCBI Protein Information: transmembrane protein 106B
• UniProt Protein Name: Transmembrane protein 106B
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM106B
• UniProt Entry Name: T106B_HUMAN

Uniprot Description

TMEM106B: TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. Belongs to the TMEM106 family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: integral to membrane; intracellular membrane-bound organelle; late endosome membrane; lysosomal membrane

Molecular Function: protein binding

Biological Process: dendrite morphogenesis; lysosome localization; transport