Leptin Receptor/LEPR/CD295 Recombinant Protein | LEPR/CD295 recombinant protein

Recombinant Mouse Leptin Receptor/LEPR/CD295 (C-10His)

Cat. Num. AAA2569344

• Gene Names: Lepr; db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: Leptin Receptor/LEPR/CD295; Recombinant Mouse Leptin Receptor/LEPR/CD295 (C-10His); Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR; LEPR/CD295 recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Leu22-Gly839

• Species: Mouse
• Tag: C-10His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Leptin Receptor is produced by our Mammalian expression system and the target gene encoding Leu22-Gly839 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

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Related Product Information for LEPR/CD295 recombinant protein

The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.

NCBI and Uniprot Product Information

• NCBI GI #: 1352612
• NCBI GeneID: 16847
• UniProt Accession #: P48356; O35686; O54986; Q61215; Q64309; Q9QWG3; Q9QWV5
• Molecular Weight: 90,887 Da
• NCBI Official Full Name: Leptin receptor
• NCBI Official Synonym Full Names: leptin receptor
• NCBI Official Symbol: Lepr
• NCBI Official Synonym Symbols: db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
• NCBI Protein Information: leptin receptor; B219; LEP-R; OB receptor; leptin receptor gene-related protein
• UniProt Protein Name: Leptin receptor
• UniProt Gene Name: Lepr
• UniProt Synonym Gene Names: Db; Obr; LEP-R; OB-R
• UniProt Entry Name: LEPR_MOUSE

Uniprot Description

LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Five alternatively spliced transcript variants have been reported.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: extracellular space; membrane; integral to plasma membrane; extracellular region; plasma membrane; integral to membrane; receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; protein binding; transmembrane receptor activity; peptide hormone binding; protein-hormone receptor activity

Biological Process: cholesterol metabolic process; G-protein coupled receptor protein signaling pathway; positive regulation of MAPKKK cascade; eating behavior; negative regulation of gluconeogenesis; negative regulation of hydrolase activity; regulation of metabolic process; angiogenesis; signal transduction; leptin-mediated signaling pathway