LAIR2 recombinant protein

Recombinant Human LAIR2 Protein

Cat. Num. AAA9141869

• Gene Names: LAIR2; CD306
• Purity: >90% by SDS-PAGE.
• Synonyms: LAIR2; Recombinant Human LAIR2 Protein; CD306; MGC71634; LAIR2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% by SDS-PAGE.
• Form/Format: Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
• Sequence: QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAP
• Sequence Length: 152

• Species: Human
• Endotoxin: < 0.1 EU/ug of the protein by LAL method.
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
• Tag: 6xHis tag at the C-terminus
• Preparation and Storage: Store the lyophilized protein at -20 degree C to -80 degree C for long term.; After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.

SDS-Page

(Recombinant Human LAIR2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 18-22 kDa.)

Related Product Information for LAIR2 recombinant protein

Description: Recombinant Human LAIR2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-Pro152) of human LAIR2 (Accession #NP_002279) fused with a 6xHis tag at the C-terminus.

Background: Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2), also known as CD36, is a 131 amino acid protein containing one lg-like C2-type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% aa identity across the signal sequence and extracellular domains, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. LAIR2 is thought to be secreted and may help modulate mucosal tolerance.

Product Categories/Family for LAIR2 recombinant protein

Immune Checkpoint

NCBI and Uniprot Product Information

• NCBI GI #: 10947101
• NCBI GeneID: 3904
• NCBI Accession #: NP_002279.2
• NCBI GenBank Nucleotide #: NP_002279.2
• UniProt Accession #: Q6ISS4
• NCBI Official Full Name: leukocyte-associated immunoglobulin-like receptor 2 isoform a
• NCBI Official Synonym Full Names: leukocyte associated immunoglobulin like receptor 2
• NCBI Official Symbol: LAIR2
• NCBI Official Synonym Symbols: CD306
• NCBI Protein Information: leukocyte-associated immunoglobulin-like receptor 2
• UniProt Protein Name: Leukocyte-associated immunoglobulin-like receptor 2
• Protein Family: Leukocyte-associated immunoglobulin-like receptor
• UniProt Gene Name: LAIR2
• UniProt Synonym Gene Names: CD306; LAIR-2
• UniProt Entry Name: LAIR2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

LAIR-2: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular region