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SDS-PAGE

LAIR2 / CD306 recombinant protein

Recombinant Human LAIR2 / CD306 Protein

Gene Names
LAIR2; CD306
Purity
> 93 % as determined by SDS-PAGE
Synonyms
LAIR2 / CD306; Recombinant Human LAIR2 / CD306 Protein; LAIR2; XXbac-BCX535A19.6; CD306; MGC71634; LAIR2 / CD306 recombinant protein
Ordering
For Research Use Only!
Host
Human Cells
Purity/Purification
> 93 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile 50mM Tris, 0.7M NaCl, pH 8.0
Sequence Length
152
Application Notes
The secreted recombinant human LAIR2 comprises 131 amino acids with a predicted molecular mass of 14.1 kDa. As a result of glycosylation, the apparent molecular mass of rh LAIR2 is approximately 22 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Gln 22
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

SDS-PAGE
Related Product Information for LAIR2 / CD306 recombinant protein
Background: Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2), also known as CD306, is a 131 amino acid protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.

Description: A DNA sequence encoding the human LAIR2 (NP_002279.2) (Met 1-Pro 152) was expressed and purified.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
14,722 Da
NCBI Official Full Name
leukocyte-associated immunoglobulin-like receptor 2 isoform a
NCBI Official Synonym Full Names
leukocyte associated immunoglobulin like receptor 2
NCBI Official Symbol
LAIR2
NCBI Official Synonym Symbols
CD306
NCBI Protein Information
leukocyte-associated immunoglobulin-like receptor 2
UniProt Protein Name
Leukocyte-associated immunoglobulin-like receptor 2
UniProt Gene Name
LAIR2
UniProt Synonym Gene Names
CD306; LAIR-2

NCBI Description

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

LAIR-2: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Process: regulation of immune response

Research Articles on LAIR2 / CD306

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Product Notes

The LAIR2 / CD306 lair2 (Catalog #AAA2546038) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant human LAIR2 comprises 131 amino acids with a predicted molecular mass of 14.1 kDa. As a result of glycosylation, the apparent molecular mass of rh LAIR2 is approximately 22 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the LAIR2 / CD306 lair2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAIR2 / CD306, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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