LAIR2 recombinant protein

LAIR2 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120530

• Gene Names: LAIR2; CD306
• Purity: >97% as determined by SDS-PAGE
• Synonyms: LAIR2; LAIR2 Protein; Human; Recombinant (His Tag); Human LAIR2/CD306 Protein (His Tag); CD306 Protein; MGC71634 Protein; XXbac-BCX535A19.6 Protein; leukocyte associated immunoglobulin like receptor 2; LAIR2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >97% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Pro152

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 22
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human LAIR2 (NP_002279.2)(Met 1-Pro 152) with a C-terminal polyhistidine tag was expressed.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for LAIR2 recombinant protein

Background: Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2), also known as CD36, is a 131 amino acid protein containing one Ig-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.

Product Categories/Family for LAIR2 recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

References

Meyaard, L. et al.,1997, Immunity.7:283-290. Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804. Meyaard, L. et al., 2001, J. Exp. Med. 194 (1): 107-112. Meyaard, L., 2003, J Biol Regul Homeost Agents. 17 (4): 330-333. Lebbink, R. J. et al., 2008, J Immunol. 180 (3):1662-1669. Lebbink,R.J. et al., 2009, Matrix Biol. 28 (4):202-210.

NCBI and Uniprot Product Information

• NCBI GI #: 10947101
• NCBI GeneID: 3904
• NCBI Accession #: NP_002279.2
• NCBI GenBank Nucleotide #: NM_002288.5
• UniProt Accession #: Q6ISS4; Q6PEZ4
• Molecular Weight: 14,722 Da
• NCBI Official Full Name: leukocyte-associated immunoglobulin-like receptor 2 isoform a
• NCBI Official Synonym Full Names: leukocyte-associated immunoglobulin-like receptor 2
• NCBI Official Symbol: LAIR2
• NCBI Official Synonym Symbols: CD306
• NCBI Protein Information: leukocyte-associated immunoglobulin-like receptor 2; LAIR-2; leukocyte-associated Ig-like receptor 2; leukocyte-associated Ig-like receptor-2
• UniProt Protein Name: Leukocyte-associated immunoglobulin-like receptor 2
• Protein Family: Leukocyte-associated immunoglobulin-like receptor
• UniProt Gene Name: LAIR2
• UniProt Synonym Gene Names: CD306; LAIR-2
• UniProt Entry Name: LAIR2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

LAIR-2: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular region