Rabbit anti-Human, Rat BPIFA1 Polyclonal Antibody | anti-BPIFA1 antibody

BPIFA1 Polyclonal Antibody

Cat. Num. AAA3006882

• Gene Names: BPIFA1; LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: BPIFA1; Polyclonal Antibody; BPIFA1 Polyclonal Antibody; BPI fold-containing family A member 1; Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl; LUNX; NASG; PLUNC; SPURT; UNQ787; PRO1606; anti-BPIFA1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BPIFA1 polyclonal antibody detects endogenous levels of BPIFA1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 256

• Applicable Applications for anti-BPIFA1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human BPIFA1
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of BPIFA1 polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:PC12 whole cell lysate)

Related Product Information for anti-BPIFA1 antibody

The upper respiratory tract is the main place of entry for pathogens to invade the body, and early recognition of bacterial products in this region is crucial for host defense. Palate lung nasal epithelial clone PLUNC (or LUNX) is an airway specific secretory protein that is expressed in epithelial tissues and submucosal glands of the oral cavity and upper respiratory tract of humans, mice, rats and cows. PLUNC binds to lipopolysaccharide (LPS) in nasal lavage fluid (NLF) which points to its role in the inflammatory response of the upper airways after exposure to irritants. Decreased levels of PLUNC occur in the NLF of smokers and people who have been exposed to reactive epoxy chemicals, indicating that long-term exposure to airway irritants impairs the production of PLUNC in the upper respiratory tract. Abnormal expression of PLUNC may influence susceptibility to nasopharyngeal carcinoma in the Chinese population.

NCBI and Uniprot Product Information

• NCBI GI #: 342307069
• NCBI GeneID: 51297
• NCBI Accession #: NP_001230122.1
• NCBI GenBank Nucleotide #: NP_001230122.1
• UniProt Accession #: Q9NP55
• Molecular Weight: ~ 27kDa
• NCBI Official Full Name: BPI fold-containing family A member 1
• NCBI Official Synonym Full Names: BPI fold containing family A member 1
• NCBI Official Symbol: BPIFA1
• NCBI Official Synonym Symbols: LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
• NCBI Protein Information: BPI fold-containing family A member 1
• UniProt Protein Name: BPI fold-containing family A member 1
• Protein Family: BPI fold-containing family
• UniProt Gene Name: BPIFA1
• UniProt Synonym Gene Names: LUNX; NASG; PLUNC; SPLUNC1; SPURT; SPLUNC1
• UniProt Entry Name: BPIA1_HUMAN

NCBI Description

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]