Structure
YM-58483, Inhibitor
YM-58483
Purity
>98% (HPLC)
Synonyms
YM-58483; YM58483; YM 58483; BPT2; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=32mg/mL
Target
CRAC Channel
Receptor
SOCE
Chemical Name
1, 2, 3-Thiadiazole-5-carboxamide, N-[4-[3, 5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl
SMILES
O=C(C1=C(C)N=NS1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2
Molecular Formula
C15H9F6N5OS
CAS Number
223499-30-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for YM-58483, inhibitor
A store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100nM; inhibits Ca (2+) influx through SOC channels without affecting the TCR signal transduction cascade in Jurkat cells, inhibits thapsigargin-induced sustained Ca (2+) influx (IC50=100nM), and 30-fold less potent against Cav channels; potently inhibits IL-2 production and NF-AT-driven promoter activity in Jurkat cells; also inhibits IL-4 and IL-5 production Th2 T cells, prevents antigen-induced inflammatory responses in animal models; orally active.
Product Categories/Family for YM-58483, inhibitor
References
1. Ishikawa J, et al. J Immunol. 2003 May 1; 170 (9):4441-9.
2. Yoshino T, et al. Eur J Pharmacol. 2007 Apr 10; 560 (2-3):225-33.
3. Takezawa R, et al. Mol Pharmacol. 2006 Apr; 69 (4):1413-20.
4. Zitt C, et al. J Biol Chem. 2004 Mar 26; 279 (13):12427-37.
2. Yoshino T, et al. Eur J Pharmacol. 2007 Apr 10; 560 (2-3):225-33.
3. Takezawa R, et al. Mol Pharmacol. 2006 Apr; 69 (4):1413-20.
4. Zitt C, et al. J Biol Chem. 2004 Mar 26; 279 (13):12427-37.
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Product Notes
The YM-58483 (Catalog #AAA3603582) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "YM-58483, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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