Structure
Avacopan, Inhibitor
Avacopan
Purity
>98% (HPLC)
Synonyms
Avacopan; CCX-168; CCX168; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=10.1mg/mL (17.36mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
Complement System
Receptor
Complement System
Chemical Name
(2R, 3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide
SMILES
O=C([C@@H]1[C@H](C2=CC=C(NC3CCCC3)C=C2)N(C(C4=C(C)C=CC=C4F)=O)CCC1)NC5=CC=C(C)C(C(F)(F)F)=C5
Molecular Formula
C33H35F4N3O2
CAS Number
1346623-17-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Avacopan, inhibitor
Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1nM; shows no activity (IC50 >5,000nM)for C5aR-related receptors C5L2, C3aR, ChemR23, GPR1 and FPR1; inhibits C5a-mediated chemotaxis of U937 cells with pA2 of 0.2nM; shows activity in mouse model of ANCA-induced glomerulonephritis. Other Indication Phase 3 Clinical
Product Categories/Family for Avacopan, inhibitor
References
1. Xiao H, et al. J Am Soc Nephrol. 2014 Feb; 25 (2):225-31.
2. Bekker P, et al. PLoS One. 2016 Oct 21; 11 (10):e0164646.
3. Jayne DRW, et al. J Am Soc Nephrol. 2017 Sep; 28 (9):2756-2767.
2. Bekker P, et al. PLoS One. 2016 Oct 21; 11 (10):e0164646.
3. Jayne DRW, et al. J Am Soc Nephrol. 2017 Sep; 28 (9):2756-2767.
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Product Notes
The Avacopan (Catalog #AAA3601405) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Avacopan, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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