Structure
Asivatrep Biochemical
Asivatrep
Purity
>98% (HPLC)
Synonyms
Asivatrep; PAC-14028; PAC14028; Asivatrep biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=28mg/mL
Target
TRP/TRPV Channel
Receptor
TRP/TRPV Channel
Chemical Name
2-Propenamide, N-[(1R)-1-[3, 5-difluoro-4-[(methylsulfonyl)amino]phenyl]ethyl]-3-[2-propyl-6-(trifluoromethyl)-3-pyridinyl]-, (2E)
SMILES
O=C(N[C@@H](C1=CC(F)=C(NS(=O)(C)=O)C(F)=C1)C)/C=C/C2=CC=C(C(F)(F)F)N=C2CCC
Molecular Formula
C21H22F5N3O3S
CAS Number
1005168-10-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Asivatrep biochemical
Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1; inhibits capsaicin-evoked calcium influx in keratinocytes at sub-micromolar concentrations, blocks capsaicin-induced blood perfusion increase, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice, also attenuates dermatitis-associated barrier damages in Df and OXZ models. Dermatitis Phase 3 Clinical
Product Categories/Family for Asivatrep biochemical
References
1. Yun JW, et al. J Dermatol Sci. 2011 Apr; 62 (1):8-15.
2. Yun JW, et al. J Invest Dermatol. 2011 Jul; 131 (7):1576-9.
3. Lim KM, et al. Arch Pharm Res. 2012 Mar; 35 (3):393-6.
2. Yun JW, et al. J Invest Dermatol. 2011 Jul; 131 (7):1576-9.
3. Lim KM, et al. Arch Pharm Res. 2012 Mar; 35 (3):393-6.
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Product Notes
The Asivatrep (Catalog #AAA3600042) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Asivatrep, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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