Structure
INX-08189, Inhibitor
INX-08189
Purity
>98% (HPLC)
Synonyms
INX-08189; INX08189; BMS-986094; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
HCV
Receptor
HCV
Chemical Name
Neopentyl((((2R, 3R, 4R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3, 4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate
SMILES
C[C@H](NP(OC1=C2C=CC=CC2=CC=C1)(OC[C@H]3O[C@@H](N4C=NC5=C(OC)N=C(N)N=C45)[C@](C)(O)[C@@H]3O)=O)C(OCC(C)(C)C)=O
Molecular Formula
C30H39N6O9P
CAS Number
1234490-83-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for INX-08189, inhibitor
A phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10nM in replicon assay; inhibits viral replication with EC50 of 35nM, inhibits mutant NS5b S282T mutant replicon with EC90 of 344nM; orally active. HCV Infection Phase 2 Discontinued
Product Categories/Family for INX-08189, inhibitor
References
1. McGuigan C, et al. Bioorg Med Chem Lett. 2010 Aug 15; 20 (16):4850-4.
2. Vernachio JH, et al. Antimicrob Agents Chemother. 2011 May; 55 (5):1843-51.
3. Ehteshami M, et al. Antimicrob Agents Chemother. 2016 Jul 22; 60 (8):4659-69.
2. Vernachio JH, et al. Antimicrob Agents Chemother. 2011 May; 55 (5):1843-51.
3. Ehteshami M, et al. Antimicrob Agents Chemother. 2016 Jul 22; 60 (8):4659-69.
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Product Notes
The INX-08189 (Catalog #AAA3600937) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "INX-08189, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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