Structure
TAS-117, Inhibitor
TAS-117
Purity
>98% (HPLC)
Synonyms
TAS-117; TAS117; inhibitor
Purity/Purification
>98% (HPLC)
Target
Akt
Receptor
Akt
Chemical Name
Trans-3-amino-1methyl-3-[4-(3-phenyl-5H-imidazo[1, 2-c]pyrido[3, 4-e][1, 3]oxazin-2-yl)phenyl]-cyclobutanol
SMILES
C[C@]1(O)C[C@@](N)(C2=CC=C(C=C2)C3=C(C4=CC=CC=C4)N5COC6=CC=NC=C6C5=N3)C1
Molecular Formula
C26H24N4O2
CAS Number
1402602-94-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TAS-117, inhibitor
TAS-117 is a highly selective, non-ATP competitive pan-Akt inhibitor with IC50 of 4.8/1.6/44nM for Akt1/Akt2/Akt3 respectively; shows minimal inhibitory activities against others kinases including PI3K, PDK1, and mTOR; inhibits Akt kinase activity but not p-Akt, blocks basal phosphorylation of Akt and downstream p-FKHR/FKHRL1; induces significant cytotoxicity in MM cells associated with inhibition of IL6 secretion; triggers apoptosis and autophagy, induces ER stress response, inhibits human MM cell growth in murine xenograft models. Solid Tumors Phase 1 Clinical
Product Categories/Family for TAS-117, inhibitor
References
1. Mimura N, et al. Cancer Res. 2014 Aug 15; 74 (16):4458-69.
2. Koji Ichikawa, et al.
2. Koji Ichikawa, et al.
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Product Notes
The TAS-117 (Catalog #AAA3601679) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TAS-117, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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