Structure
CCT128930, Inhibitor
CCT128930
Purity
>98% (HPLC)
Synonyms
CCT128930; CCT 128930; CCT-128930; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Akt
Receptor
Akt2 , p70 S6K , PKA
Chemical Name
4-Piperidinamine, 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)
SMILES
NC1(CC2=CC=C(Cl)C=C2)CCN(C3=C4C(NC=C4)=NC=N3)CC1
Molecular Formula
C18H20ClN5
CAS Number
885499-61-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CCT128930, inhibitor
CCT128930 is a potent, selective, ATP-competitive AKT inhibitor with IC50 of 6nM (AKT2), 28-fold selectivity over the closely related PKA; also exhibits 20-fold selectivity over p70S6K (IC50=120nM); shows growth inhibition for U87MG human glioblastoma cells (IC50=6.3uM), for LNCaP human prostate cancer cells (IC50=0.35uM), and for PC3 human prostate cancer cells (IC50=1.9uM) consistent with AKT pathway blockade; blocks the phosphorylation of several downstream AKT biomarkers in U87MG tumor xenografts, indicating AKT inhibition in vivo; demonstrates antitumor activity in U87MG and HER2-positive, PIK3CA-mutant BT474 human breast cancer xenografts.
Product Categories/Family for CCT128930, inhibitor
References
1. Caldwell JJ, et al. J Med Chem. 2008 Apr 10; 51 (7):2147-57.
2. Yap TA, et al. Mol Cancer Ther. 2011 Feb; 10 (2):360-71.
3. Yap TA, et al. Clin Cancer Res. 2012 Jul 15; 18 (14):3912-23.
2. Yap TA, et al. Mol Cancer Ther. 2011 Feb; 10 (2):360-71.
3. Yap TA, et al. Clin Cancer Res. 2012 Jul 15; 18 (14):3912-23.
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Product Notes
The CCT128930 (Catalog #AAA3606404) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CCT128930, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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