Structure
TAS-116, Inhibitor
TAS-116
Purity
>98% (HPLC)
Synonyms
TAS-116; TAS 116; TAS116; inhibitor
Purity/Purification
>98% (HPLC)
Target
HSP
Receptor
HSP
Chemical Name
3-Ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3, 4-b]pyridin-1-yl]benzamide
SMILES
O=C(NCC)C1=CC=C(N2N=C(C(C)C)C3=C(N4C=C(C5=CN(C)N=C5)N=C4)C=CN=C32)C=C1
Molecular Formula
C25H26N8O
CAS Number
1260533-36-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TAS-116, inhibitor
TAS-116 is a novel potent, selective, orally available HSP90alpha/beta inhibitor with Ki of 34.7, 21.3, >50,000, and >50,000nM for HSP90alpha, HSP90beta, GRP94, and TRAP1, respectively; induces cytotoxicity selectively and potently in MM cell lines and patient MM cells, without toxicity in normal PBMNCs; potently targets HSP90 client proteins including C-Raf and MEK1/2; also inhibits upregulation of HSP27 and overcomes 17-AAG resistance mechanisms in MM cells; demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models. Gastric Cancer Phase 2 Clinical
Product Categories/Family for TAS-116, inhibitor
References
1. Suzuki R, et al. Leukemia. 2015 Feb; 29 (2):510-4.
2. Ohkubo S, et al. Mol Cancer Ther. 2015 Jan; 14 (1):14-22.
3. Suzuki R, et al. PLoS One. 2015 Dec 2; 10 (12):e0143847.
2. Ohkubo S, et al. Mol Cancer Ther. 2015 Jan; 14 (1):14-22.
3. Suzuki R, et al. PLoS One. 2015 Dec 2; 10 (12):e0143847.
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Product Notes
The TAS-116 (Catalog #AAA3601077) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TAS-116, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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