Structure
BAY-1125976, Inhibitor
BAY-1125976
Purity
>98% (HPLC)
Synonyms
BAY-1125976; BAY1125976; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 10.33mg/mL
Target
Akt
Receptor
Akt
Chemical Name
Imidazo[1, 2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl
SMILES
C1CC(C1)(C2=CC=C(C=C2)C3=C(N4C(=N3)C=CC(=N4)C(=O)N)C5=CC=CC=C5)N
Molecular Formula
C23H21N5O
CAS Number
1402608-02-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY-1125976, inhibitor
A potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18nM at 10uM ATP; binds to active AKT1 with Kd of 2.7nM and inactive AKT1 with Kd of 1.3nM. displays >86-fold less potent against AKT3; inhibits the phosphorylation of AKT1 at T308 and S473 (IC50=0.9 and 1.1nM, respectively), PRAS40 at T246 and 4EBP1 at T70; targets tumors displaying PI3K/AKT/mTOR pathway activation, inhibits cell proliferation in a broad panel of human cancer cell lines, particularly in breast and prostate cancer cell lines expressing estrogen or androgen receptors; exhibits strong in vivo patient-derived xenograft models.
Product Categories/Family for BAY-1125976, inhibitor
References
1. Politz O, et al. Int J Cancer. 2017 Jan 15; 140 (2):449-459.
Similar Products
Product Notes
The BAY-1125976 (Catalog #AAA3601680) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY-1125976, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
