Structure
STA 2842, Inhibitor
STA 2842
Purity
>98% (HPLC)
Synonyms
STA 2842; STA2842; inhibitor
Purity/Purification
>98% (HPLC)
Target
HSP
Receptor
HSP
Chemical Name
5-(2, 4-dihydroxy-5-isopropylphenyl)-N-(2-morpholinoethyl)-4-(4-(morpholinomethyl)phenyl)-4H-1, 2, 4-triazole-3-carboxamide
SMILES
O=C(C1=NN=C(C2=CC(C(C)C)=C(O)C=C2O)N1C3=CC=C(CN4CCOCC4)C=C3)NCCN5CCOCC5
Molecular Formula
C29H38N6O5
CAS Number
1046490-67-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for STA 2842, inhibitor
STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135nM, HSP90alpha) that competitively binds the N-terminal ATP pocket of HSP90; induces the degradation of many ADPKD-relevant HSP90 client proteins in Pkd1 (-/-) primary kidney cells and in vivo; significantly reduces initial formation of renal cysts and kidney growth and slows the progression of these phenotypes in mice with preexisting cysts.
Product Categories/Family for STA 2842, inhibitor
References
1. Seeger-Nukpezah T, et al. Proc Natl Acad Sci U S A. 2013 Jul 30; 110 (31):12786-91.
2. Nikonova AS, et al. Proc Natl Acad Sci U S A. 2014 Sep 2; 111 (35):12859-64.
3. Smithline ZB, et al. PLoS One. 2014 Dec 4; 9 (12):e114403.
2. Nikonova AS, et al. Proc Natl Acad Sci U S A. 2014 Sep 2; 111 (35):12859-64.
3. Smithline ZB, et al. PLoS One. 2014 Dec 4; 9 (12):e114403.
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Product Notes
The STA 2842 (Catalog #AAA3600232) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "STA 2842, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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