Structure
NSC 145366, Inhibitor
NSC 145366
Purity
>98% (HPLC)
Synonyms
NSC 145366; NSC145366; inhibitor
Purity/Purification
>98% (HPLC)
Target
HSP
Receptor
HSP
Chemical Name
1-[4-[2-[4-[2-hydroxy-3-(2, 4, 4-trimethylpentan-2-ylamino)propoxy]phenyl]propan-2-yl]phenoxy]-3-(2, 4, 4-trimethylpentan-2-ylamino)propan-2-ol hydrochloride
SMILES
CC(C1=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C1)(C2=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C2)C.[H]Cl.[H]Cl
Molecular Formula
C37H63ClN2O4
CAS Number
1052515-37-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NSC 145366, inhibitor
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.
Product Categories/Family for NSC 145366, inhibitor
References
1. Thomas FM, et al. SLAS Discov. 2017 Jul; 22 (6):706-719.
2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug; 1861 (8):1992-2006.
2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug; 1861 (8):1992-2006.
Similar Products
Product Notes
The NSC 145366 (Catalog #AAA3600250) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NSC 145366, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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