Structure
SNX-0723, Inhibitor
SNX-0723
Purity
>98% (HPLC)
Synonyms
SNX-0723; SNX 0723; SNX0723; inhibitor
Purity/Purification
>98% (HPLC)
Target
HSP
Receptor
HSP
Chemical Name
2-fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(3, 6, 6-trimethyl-4-oxo-5, 7-dihydroindol-1-yl)benzamide
SMILES
O=C(N)C1=C(N[C@@H]2COCC2)C=C(N3C=C(C)C4=C3CC(C)(C)CC4=O)C=C1F
Molecular Formula
C22H26FN3O3
CAS Number
1073969-18-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SNX-0723, inhibitor
SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14nM) that inhibits alpha-synuclein oligomerization with EC50 of 48nM; induces Hsp70 (IC50=31nM), and decreases expression of several known Hsp90 client proteins:HER2 (IC50=9.4nM), ribosomal protein s6 (pS6) (IC50=13nM), and PERK (IC50=5.5nM); shows significant brain concentrations along with induction of brain Hsp70 in vivo with promising PK properties.
Product Categories/Family for SNX-0723, inhibitor
References
1. Putcha P, J Pharmacol Exp Ther. 2010 Mar; 332 (3):849-57.et al.
2. McFarland NR, et al. PLoS One. 2014 Jan 20; 9 (1):e86048.
3. Neubert T, et al. Bioorg Med Chem Lett. 2015 Mar 15; 25 (6):1338-42.
2. McFarland NR, et al. PLoS One. 2014 Jan 20; 9 (1):e86048.
3. Neubert T, et al. Bioorg Med Chem Lett. 2015 Mar 15; 25 (6):1338-42.
Similar Products
Product Notes
The SNX-0723 (Catalog #AAA3600305) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SNX-0723, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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