Structure
KUNB 31, Inhibitor
KUNB 31
Purity
>98% (HPLC)
Synonyms
KUNB 31; KUNB31; inhibitor
Purity/Purification
>98% (HPLC)
Target
HSP
Receptor
HSP
Chemical Name
(4-hydroxy-7-isopropylbenzo[d]isoxazol-5-yl)(isoindolin-2-yl)methanone
SMILES
O=C(C1=CC(C(C)C)=C(ON=C2)C2=C1O)N3CC4=C(C=CC=C4)C3
Molecular Formula
C19H18N2O3
CAS Number
2220263-80-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for KUNB 31, inhibitor
KUNB 31 is a potent, isoform-selective Hsp90beta inhibitor with Kd of 0.18uM, displays 50-fold selectivity over Hsp90alpha and Grp94; exhibits anti-proliferative activity against NCI H23, UC3, and HT-29 cancer cell lines with IC50 of 6.74uM, 3.01uM, and 3.72uM, respectively; specificly induces the degradation of Hsp90beta-dependent client proteins (EGFR, HER2, CDK4, CDK6, CXCR4 etc.) in cells.
Product Categories/Family for KUNB 31, inhibitor
References
1. Khandelwal A, et al. Nat Commun. 2018 Jan 30; 9 (1):425.
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Product Notes
The KUNB 31 (Catalog #AAA3603540) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KUNB 31, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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