Structure
GW406108X, Inhibitor
GW406108X
Purity
>98% (HPLC)
Synonyms
GW406108X; GW-406108X; GW108X; inhibitor
Purity/Purification
>98% (HPLC)
Target
Kinesin
Receptor
Kinesin
Chemical Name
(Z)-3-(3, 5-dichloro-4-hydroxybenzylidene)-5-(furan-2-carbonyl)indolin-2-one
SMILES
C1=COC(=C1)C(=O)C2=CC3=C(C=C2)NC(=O)C3=CC4=CC(=C(C(=C4)Cl)O)Cl
Molecular Formula
C20H11Cl2NO4
CAS Number
1644443-92-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GW406108X, inhibitor
GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82uM in ATPase assays; GW108X displays a preference for Kif15 over the other mitotic motors, with 30uM of GW108X inhibiting Kif15 MT gliding by 98.9% +/- 0.2% while only inhibiting Eg5 by 19.8% +/- 4.3%, HSET by 5.3% +/- 2.9% and Kif18A by 4.9%; inhibits the MT-stimulated ATPase and MT gliding activity of Kif15 either by inhibiting ATP binding or by inhibiting MT binding by the motorl; shows a distinct mechanism of action compared with the Kif15 inhibitor, Kif15-IN-1.
Product Categories/Family for GW406108X, inhibitor
References
1. Dumas ME, et al. Bioorg Med Chem Lett. 2019 Jan 15; 29 (2):148-154.
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Product Notes
The GW406108X (Catalog #AAA3602508) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GW406108X, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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