Structure
Spautin-1, Inhibitor
Spautin-1
Purity
>98% (HPLC)
Synonyms
Spautin-1; Spautin1; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 27.1mg/mL (100mM) (<1mg/mL refers to the product slightly soluble or insoluble)
Target
DUB
Receptor
USP10; USP13
Chemical Name
6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
SMILES
FC1=CC=C(CNC2=C3C=C(F)C=CC3=NC=N2)C=C1
Molecular Formula
C15H11F2N3
CAS Number
1262888-28-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Spautin-1, inhibitor
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7uM, but not USP14; promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity; promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence ofmg132; sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).
Product Categories/Family for Spautin-1, inhibitor
References
1. Liu J, et al. Cell. 2011 Sep 30; 147 (1):223-34.
2. Li Y, et al. Nat Commun. 2017 Jun 1; 8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb; 87 (3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1; 27 (15):1718-30.
2. Li Y, et al. Nat Commun. 2017 Jun 1; 8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb; 87 (3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1; 27 (15):1718-30.
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Product Notes
The Spautin-1 (Catalog #AAA3601101) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Spautin-1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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