Testing Data
Tandutinib, Inhibitor
Tandutinib (MLN518)
Purity
>99%
Synonyms
Tandutinib; Tandutinib (MLN518); inhibitor
Purity/Purification
>99%
Solubility
DMSO >=11mg/mL - Water <1mg/mL - Ethanol >=19mg/mL
Formula
C31H42N6O4
CAS Number
387867-13-2
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for Tandutinib, inhibitor
The FMS-like tyrosine kinase 3 (FLT3) protein is a receptor tyrosine kinase that is expressed at high levels in 70-100% of cases of AML(Acute myeloid leukemia) and has been identified as potential target for molecular therapy. Internal tandem duplications (ITD) of the juxtamembrane domain in FLT3 occur regularly in de novo AML, resulting in constitutive activation of FLT3 tyrosine kinase activity. [1] In cell-based assays tandutinib inhibited FLT3, PDGFR, and KIT with IC50 values of 95-122 ng/mL, but had no significant effect against a broad range of other kinases. In Ba/F3 cells expressing various FLT3-ITD mutants, tandutinib inhibited IL-3-independent growth and FLT3-ITD auto-phosphorylation with IC50 values of 6-17 ng/ml. Tandutinib also inhibited in vitro proliferation of human leukemia cell lines containing FLT3-ITD mutations with IC50 values of approximately 6 ng/mL. [2] Tandutinib has a very limited spectrum of activity outside the type III receptor kinase family. Evaluation of tandutinib in rats, dogs, and monkeys showed it to be orally bioavailable, metabolically stable. Phase I clinical results with tandutinib (MLN518) in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics.
Product Categories/Family for Tandutinib, inhibitor
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Product Notes
The Tandutinib (Catalog #AAA8506238) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tandutinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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