Testing Data
WZ3146, inhibitor
WZ3146
Purity
>99%
Synonyms
WZ3146; inhibitor
Purity/Purification
>99%
Solubility
DMSO >=93mg/mL - Water <1mg/mL - Ethanol >=3mg/mL
Formula
C24H25ClN6O2
CAS Number
1214265-56-1
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for WZ3146, inhibitor
WZ3146 is an irreversiblely inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ3146 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors.This agent is 30-to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387, 785) in vitro.WZ3146 has a 300-fold lower half-maximum inhibitory concentration (IC50<10nM) against the PC9GR(delE746_A750/T790M, gefitinib-resistant) cells compared with clinical-stage inhibitors such as HKI-272.
Product Categories/Family for WZ3146, inhibitor
References
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M Wenjun Zhou1, Dalia Ercan, et al. Nature 2009 December; 462(7276): 1070-1074 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The WZ3146 (Catalog #AAA8506323) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "WZ3146, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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