Structure
S49076 hydrochloride, Inhibitor
S49076 hydrochloride
Purity
>98% (HPLC)
Synonyms
S49076 hydrochloride; S 49076; S-49076; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: Soluble (<1mg/mL refers to the product slightly soluble or insoluble)
Target
TAM Receptor
Receptor
AXL; FGFR1; FGFR2; FGFR3; MER; Met
Chemical Name
3-[[2, 3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-2, 4-thiazolidinedione hydrochloride
SMILES
C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl
Molecular Formula
C22H23ClN4O4S
CAS Number
1265966-31-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for S49076 hydrochloride, inhibitor
S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2; only inhibits 6% of kinases on a panel of 442 human wild-type and mutated kinases at 100nM; inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL; causes tumor growth arrest in bevacizumab-resistant tumors in cancer xenograft models. Brain Cancer Phase 2 Clinical
Product Categories/Family for S49076 hydrochloride, inhibitor
References
1. Burbridge MF, et al. Mol Cancer Ther. 2013 Sep; 12 (9):1749-62.
2. Cliemenson C, et al. Mol Cancer Ther. 2017 Oct; 16 (10):2107-2119.
3. Rodon J, et al. Eur J Cancer. 2017 Aug; 81:142-150.
2. Cliemenson C, et al. Mol Cancer Ther. 2017 Oct; 16 (10):2107-2119.
3. Rodon J, et al. Eur J Cancer. 2017 Aug; 81:142-150.
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Product Notes
The S49076 hydrochloride (Catalog #AAA3601116) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "S49076 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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