Structure
MK-2461, Inhibitor
MK-2461
Purity
>98% (HPLC)
Synonyms
MK-2461; MK 2461; MK2461; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=31mg/mL
Target
c-Met/HGFR
Receptor
c-Met (M1250T); c-Met (N1100); c-Met (Y1230C); c-Met (Y1230H); c-Met (Y1235D)
Chemical Name
Sulfamide, N-[(2R)-1, 4-dioxan-2-ylmethyl]-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4, 5]cyclohepta[1, 2-b]pyridin-7-yl]
SMILES
O=S(NC1=CC=C2C(C(C3=CC(C4=CN(C)N=C4)=CN=C3C=C2)=O)=C1)(N(C[C@H]5OCCOC5)C)=O
Molecular Formula
C24H25N5O5S
CAS Number
917879-39-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-2461, inhibitor
MK-2461 is a potent multitargeted kinase inhibitor that preferentially inhibits c-Met with IC50 of 2.5nM, with similar potencies for Ron and Flt1 (IC50=7 and 10nM, respectively); 8- to 30-fold less sensitive to FGFR1, FGFR2, FGFR3, PDGFRbeta, KDR, Flt3, Flt4, TrkA, and TrkB; is equally or more potent against 5 c-Met mutants (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC50 of 0.4-2.5nM; inhibits c-Met-dependent mitogenesis, migration, cell scatter, and tubulogenesis in cells; suppresses tumor growth a murine xenograft model of c-Met-dependent gastric cancer; orally active. Solid Tumors Phase 2 Clinical
Product Categories/Family for MK-2461, inhibitor
References
1. Pan BS, et al. Cancer Res. 2010 Feb 15; 70 (4):1524-33.
2. Rickert KW, et al. J Biol Chem. 2011 Apr 1; 286 (13):11218-25.
3. Katz JD, et al. J Med Chem. 2011 Jun 23; 54 (12):4092-108.
2. Rickert KW, et al. J Biol Chem. 2011 Apr 1; 286 (13):11218-25.
3. Katz JD, et al. J Med Chem. 2011 Jun 23; 54 (12):4092-108.
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Product Notes
The MK-2461 (Catalog #AAA3606583) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-2461, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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