Structure
Infigratinib, Inhibitor
Infigratinib
Purity
>98% (HPLC)
Synonyms
Infigratinib; NVP-BGJ398; BGJ-398; BGJ398; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 27mg/mL
Target
FGFR
Receptor
FGFR1; FGFR2; FGFR3; FGFR3 (K650E); FGFR4
Chemical Name
Urea, N'-(2, 6-dichloro-3, 5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl
SMILES
CCN1CCN(CC1)C1=CC=C(NC2=CC(=NC=N2)N(C)C(=O)NC2=C(Cl)C(OC)=CC(OC)=C2Cl)C=C1
Molecular Formula
C26H31Cl2N7O3
CAS Number
872511-34-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Infigratinib, inhibitor
Infigratinib (NVP-BGJ398, BGJ398) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9nM; inhibits the proliferation of the FGFR1-, FGFR2-, and FGFR3-dependent BaF3 cells with IC50 of low nanomolar range; shows significant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3, significantly inhibits the growth of FGFR2-mutated endometrial cancer xenograft models, also ameliorates FGF23-mediated hypophosphatemic rickets in mouse models. Blood Cancer Phase 2 Clinical
Product Categories/Family for Infigratinib, inhibitor
References
1. Guagnano V, et al. J Med Chem. 2011 Oct 27; 54 (20):7066-83.
2. Guagnano V, et al. Cancer Discov. 2012 Dec; 2 (12):1118-33.
3. Konecny GE, et al. Mol Cancer Ther. 2013 May; 12 (5):632-42.
2. Guagnano V, et al. Cancer Discov. 2012 Dec; 2 (12):1118-33.
3. Konecny GE, et al. Mol Cancer Ther. 2013 May; 12 (5):632-42.
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Product Notes
The Infigratinib (Catalog #AAA3606339) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Infigratinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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