Structure
Rucaparib, Inhibitor
Rucaparib
Purity
>98% (HPLC)
Synonyms
Rucaparib; AG014699; PF01367338; AG 014699; PF 01367338; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PARP
Receptor
PARP1
Chemical Name
6H-Pyrrolo[4, 3, 2-ef][2]benzazepin-6-one, 8-fluoro-1, 3, 4, 5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]
SMILES
CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
Molecular Formula
C19H18FN3O
CAS Number
283173-50-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Rucaparib, inhibitor
An inhibitor of PARP with Ki of 1.4nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains; inhibits PARP-1 activity by 97.1% at a concentration of 1uM in permeabilised D283Med cells; enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts. Ovarian Cancer Approved
Product Categories/Family for Rucaparib, inhibitor
References
1. Thomas HD, et al. Mol Cancer Ther, 2007, 6 (3), 945-956.
2. Daniel RA, et al. Clin Cancer Res, 2009, 15 (4), 1241-1249.
3. Daniel RA, et al. Br J Cancer, 2010, 103 (10), 1588-1596.
2. Daniel RA, et al. Clin Cancer Res, 2009, 15 (4), 1241-1249.
3. Daniel RA, et al. Br J Cancer, 2010, 103 (10), 1588-1596.
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Product Notes
The Rucaparib (Catalog #AAA3603860) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rucaparib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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