Structure
E7449, Inhibitor
E7449
Purity
>98% (HPLC)
Synonyms
E7449; E-7449; 2X-121; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: <6.96mg/mL
Target
PARP
Receptor
PARP
Chemical Name
3H-Pyridazino[3, 4, 5-de]quinazolin-3-one, 8-[(1, 3-dihydro-2H-isoindol-2-yl)methyl]-1, 2-dihydro
SMILES
O=C1NN=C(N2)C3=C(C=CC=C31)N=C2CN(C4)CC5=C4C=CC=C5
Molecular Formula
C18H15N5O
CAS Number
1140964-99-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for E7449, inhibitor
E7449 (2X-121) is a potent, orally bioavailable, brain penetrable dual inhibitor of PARP1/2 and TNKS1/2 with IC50 of 2.0/1.0nM (PARP1/2), 50-100nM (TNKS1/2); displays no significant inhibitory activity for PARP3 or PARPs6-16; shows sensitivity to cells deficient in DNA repair pathways beyond homologous recombination, inhibits Wnt/beta-catenin signaling in colon cancer cell lines, stabilizes axin and TNKS proteins resulting in beta-catenin de-stabilization and significantly alters expression of Wnt target genes; potentiates antitumor activity of chemotherapies temozolomide and carboplatin both in vitro and in vivo. Breast Cancer Phase 2 Clinical
Product Categories/Family for E7449, inhibitor
References
1. McGonigle S, et al. Oncotarget. 2015 Dec 1; 6 (38):41307-23.
2. Sharon McGonigle, et al. Abstract 4688: E7449: A novel PARP inhibitor enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. Cancer Research: April 15, 2012; Volume 72, Issue 8, Su
2. Sharon McGonigle, et al. Abstract 4688: E7449: A novel PARP inhibitor enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. Cancer Research: April 15, 2012; Volume 72, Issue 8, Su
Similar Products
Product Notes
The E7449 (Catalog #AAA3600499) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "E7449, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
