Structure
Veliparib, Inhibitor
Veliparib
Purity
>98% (HPLC)
Synonyms
Veliparib; ABT-888; ABT 888; ABT888; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=29mg/mL
Target
PARP
Receptor
PARP1; PARP2
Chemical Name
1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]
SMILES
C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
Molecular Formula
C13H16N4O
CAS Number
912444-00-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Veliparib, inhibitor
Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9nM for PARP-1 and PARP-2, respectively; displays no activity against SIRT2 and selective biochemical profile in a panel of 74 receptor-binding assays; strongly potentiates temozolomide in the B16F10 s. C. murine melanoma model, also potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models. Breast Cancer Phase 3 Clinical
Product Categories/Family for Veliparib, inhibitor
References
1. Donawho CK, et al. Clin Cancer Res. 2007 May 1; 13 (9):2728-37.
2. Albert JM, et al. Clin Cancer Res. 2007 May 15; 13 (10):3033-42.
3. Liu X, et al. Mol Cancer Res. 2008 Oct; 6 (10):1621-9.
4. Palma JP, et al. Anticancer Res. 2008 Sep-Oct; 28 (5A):2625-35.
2. Albert JM, et al. Clin Cancer Res. 2007 May 15; 13 (10):3033-42.
3. Liu X, et al. Mol Cancer Res. 2008 Oct; 6 (10):1621-9.
4. Palma JP, et al. Anticancer Res. 2008 Sep-Oct; 28 (5A):2625-35.
Similar Products
Product Notes
The Veliparib (Catalog #AAA3606542) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Veliparib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
