Structure
MK-4827 tosylate, Inhibitor
MK-4827 tosylate
Purity
>98% (HPLC)
Synonyms
MK-4827 tosylate; Niraparib tosylate; MK 4827 tosylate; MK4827 tosylate; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=490mg/mL
Target
PARP
Receptor
PARP1; PARP2
Chemical Name
2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, 4-methylbenzenesulfonate(1:1)
SMILES
CC1=CC=C(C=C1)S(=O)(=O)O.C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Molecular Formula
C26H28N4O4S
CAS Number
1038915-73-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-4827 tosylate, inhibitor
A highly potent PARP inhibitor with IC50 of 3.8nM/2.1nM for PARP1/PARP2; inhibits PARP activity with EC50=4nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10100nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. Ovarian Cancer Approved
Product Categories/Family for MK-4827 tosylate, inhibitor
References
1. Jones P, et al. J Med Chem. 2009 Nov 26; 52 (22):7170-85.
2. Bridges KA, et al. Oncotarget. 2014 Jul 15; 5 (13):5076-86.
3. Mirza MR, et al. N Engl J Med. 2016 Dec 1; 375 (22):2154-2164.
2. Bridges KA, et al. Oncotarget. 2014 Jul 15; 5 (13):5076-86.
3. Mirza MR, et al. N Engl J Med. 2016 Dec 1; 375 (22):2154-2164.
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Product Notes
The MK-4827 tosylate (Catalog #AAA3600196) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-4827 tosylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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