Structure
NVP-BKM120 hydrochloride, Inhibitor
NVP-BKM120 hydrochloride
Purity
>98% (HPLC)
Synonyms
NVP-BKM120 hydrochloride; BKM-120 hydrochloride; Buparlisib hydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PI3K
Receptor
PI3K
Chemical Name
2-Pyridinamine, 5-(2, 6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-, hydrochloride(1:1)
SMILES
C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4.Cl
Molecular Formula
C18H22ClF3N6O2
CAS Number
1312445-63-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NVP-BKM120 hydrochloride, inhibitor
A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52nM/166nM/116nM/262nM for p110alpha/beta/delta/gamma, respectively; much less effectively inhibits the class III PI3K Vps34 and mTOR, and has no effect on PI4Kbeta and several other kinases; prevents the growth of assorted cancer cell lines when used at 5uM and inhibits tumor growth in vivo. Blood Cancer Phase 2 Clinical
Product Categories/Family for NVP-BKM120 hydrochloride, inhibitor
References
1. Maira SM, et al. Mol Cancer Ther. 2012 Feb; 11 (2):317-28.
2. Pei Y, et al. Cancer Cell. 2012 Feb 14; 21 (2):155-67.
3. Koul D, et al. Clin Cancer Res. 2012 Jan 1; 18 (1):184-95.
2. Pei Y, et al. Cancer Cell. 2012 Feb 14; 21 (2):155-67.
3. Koul D, et al. Clin Cancer Res. 2012 Jan 1; 18 (1):184-95.
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Product Notes
The NVP-BKM120 hydrochloride (Catalog #AAA3601254) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NVP-BKM120 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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