Rabbit MAP3K13 Polyclonal Antibody | anti-MAP3K13 antibody

MAP3K13 Antibody

Cat. Num. AAA7052125

• Gene Names: MAP3K13; LZK; MLK; MEKK13
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >95%, Protein G purified
• Synonyms: MAP3K13; Polyclonal Antibody; MAP3K13 Antibody; Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK; LZK; anti-MAP3K13 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid

• Applicable Applications for anti-MAP3K13 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:5000; IHC: 1:20-1:200
• Immunogen: Recombinant Human Mitogen-activated protein kinase kinase kinase 13 protein (506-835AA)
• Conjugate: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Species: Homo sapiens (Human)
• Research Area: Signal Transduction
• Target Names: MAP3K13
• Species: Homo sapiens (Human)
• Research Area: Signal Transduction
• Target Names: MAP3K13
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: Rat liver tissue,Rat lung tissue,Mouse liver tissue,Mouse stomach tissueAll lanes: MAP3K13 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 109,18,93,86,15 KDaObserved band size: 109 KDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7052125 at dilution of 1:100)

Related Product Information for anti-MAP3K13 antibody

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

NCBI and Uniprot Product Information

• NCBI GI #: 334085268
• NCBI GeneID: 9175
• NCBI Accession #: NP_001229243.1
• NCBI GenBank Nucleotide #: NM_001242314.1
• UniProt Accession #: O43283; Q05BY6; Q15450; Q2NKN3; B2R6U2; B4DLE3; B4DMV2; B4DZJ4; D3DNU1
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase 13 isoform 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 13
• NCBI Official Symbol: MAP3K13
• NCBI Official Synonym Symbols: LZK; MLK; MEKK13
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 13
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 13
• Protein Family: Mitogen-activated protein kinase kinase kinase
• UniProt Gene Name: MAP3K13
• UniProt Synonym Gene Names: MLK

NCBI Description

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

LZK: a TKL kinase of the MLK family. Synergizes with antioxidant protein-1 to activate NF-kappaB. Forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. This kinase can phosphorylate and activate JNK and MKK7. Contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif.

Protein type: EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: IkappaB kinase complex; membrane

Molecular Function: identical protein binding; MAP kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase binding; protein serine/threonine kinase activity

Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation