Structure
NSC 368262, Inhibitor
NSC 368262
Purity
>98% (HPLC)
Synonyms
NSC 368262; NSC368262; inhibitor
Purity/Purification
>98% (HPLC)
Target
STAT
Receptor
STAT
Chemical Name
6-[(pyridin-2-ylamino)-(3, 4, 5-trimethoxyphenyl)methyl]-1, 3-benzodioxol-5-ol
SMILES
OC1=C(C(NC2=NC=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1
Molecular Formula
C22H22N2O6
CAS Number
299421-08-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NSC 368262, inhibitor
NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models.
Product Categories/Family for NSC 368262, inhibitor
References
1. Buettner R, et al. ACS Chem Biol. 2011 May 20; 6 (5):432-43.
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Product Notes
The NSC 368262 (Catalog #AAA3603922) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NSC 368262, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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