Structure
NSC 185058 Biochemical
NSC 185058
Purity
>98% (HPLC)
Synonyms
NSC 185058; NSC185058; NSC-185058; 2-Pyridinecarbothioamide; NSC 185058 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 30mg/mL (139.36mM)
Ethanol: 2.5mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: 2.5mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Atg
Receptor
ATG4B; Autophagy
Chemical Name
N-pyridin-2-ylpyridine-2-carbothioamide
SMILES
S=C(C1=NC=CC=C1)NC2=NC=CC=C2
Molecular Formula
C11H9N3S
CAS Number
39122-38-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NSC 185058 biochemical
NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50uM, with no effect on mTOR and PI3K activities; directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo; markedly slows tumor growth and provides a significant survival benefit in GBM xenografts combined with radiotherapy.
Product Categories/Family for NSC 185058 biochemical
References
1. Akin D, et al. Autophagy. 2014; 10 (11):2021-35.
2. Huang T, et al. Cancer Cell. 2017 Dec 11; 32 (6):840-855.e8.
2. Huang T, et al. Cancer Cell. 2017 Dec 11; 32 (6):840-855.e8.
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Product Notes
The NSC 185058 (Catalog #AAA3604345) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NSC 185058, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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